Most drugs of abuse target the brains reward system by flooding it with dopamine for more information on drugs and the brain . Drugs dopamine and the reward system all addictive drugs overstimulate dopamine in the brains reward system creating a high. Brain reward pathways the most important reward pathway in brain is the mesolimbic dopamine system natural reward drug of abuse . Neuroanatomy and physiology of the brain reward system in substance abuse i introduction how does experimental use of substances of abuse lead to drug
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