1 nat rev neurosci 2008 jan9165 75 synaptic plasticity memory and the hippocampus a neural network approach to causality neves g1 cooke sf . The chapter opens with a brief historical account of the first two decades of research into about long term potentiation ltp and long term depression ltd section . This is the second time that i have had the honor of opening an interna tional symposium dedicated to the functions of the hippocampus here in pecs it was a . Mechanisms underlying synaptic plasticity in the hippocampus research into the mechanisms underlying ltp and ltd in the ca1 region of the hippocampus is
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