Abstract serotonin receptors 5 htrs mediate both central and peripheral control on numerous physiological functions such as sleep wake cycle thermoregulation food intake nociception locomotion sexual behavior gastrointestinal motility blood coagulation and cardiovascular homeostasis. A comprehensive state of the art review of our current understanding of the molecular and structural biology of 5 ht receptors and their potential use for drug discovery the authors describe the anatomical cellular and subcellular distribution of 5 ht receptors and demonstrate a powerful
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